Players assume the role of Kyle Crane (Roger Craig Smith), an undercover operative sent to infiltrate the quarantine zone in the fictional city of Harran, based off ancient Turkey, as his mission is to find Kadir "Rais" Suleiman (Jim Pirri), a political figure gone rogue who has a file that could destroy the reputation of his agency. But when he arrives, he must decide between completing his mission or helping the other survivors, who are being led by Harris Brecken (Matthew Wolf).