It is the end of days and ungodly powers isolate the Earth. The worlds' alliance with the heavens has been threatened by a dark and malevolent force – the mysterious Lords of Shadow. Across this shattered land, the souls of the dead wander unable to find peace, whilst creatures of evil wreak chaos and death upon the living.

Gabriel Belmont is a member of the Brotherhood of Light, an elite group of holy knights who protect and defend the innocent against the supernatural. His beloved wife was brutally murdered by the evil forces of darkness and her soul trapped for eternity. Neither living nor dead she realizes the horrific truth of what is at stake and guides Gabriel to his destiny – and hopefully salvation for the world.

Castlevania: Lords of Shadow casts the player as the mysterious Gabriel. At its heart it is a vast third-person-viewed adventure, but combat and puzzle solving also play a major part in the main quest, while dark artefacts can be used to enhance Gabriel's powers.