Cel Damage HD is a remake of a cartoony take on vehicular combat games like Twisted Metal. The story focuses on six cartoon characters from a fictional cartoon show called "Cel Damage". The characters annihilate each other to the delight of TV audiences and, since they are cartoons, instantly regenerate. The player battles through thirteen different levels and three game modes. Weaponry for Cel Damage includes cartoon staples like vacuum nozzles and portable holes, mundane weaponry like chainsaws and baseball bats, and items like freeze rays, giant springs, and portable nuclear devices.